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Michael Sheen and Lizzy Caplan star as renowned obstetrician Dr William Masters and divorced mother Virginia Johnson, whose pioneering research into human sexuality is complicated by their increasingly intimate relationship. Every season. William Masters teams up with divorced mother Virginia Johnson to conduct pioneering research that unleashes the sexual revolution.

William Masters and Virginia Johnson. Together they become pioneers in the science of sex by undertaking a groundbreaking study of the physiological aspect of the human sexual response. In the wake of their fallout, Masters and Johnson search for purpose in a world without one another, and look to the work as their personal lives crash down around them. Masters and Johnson turn to new partners in an effort to put the past behind them and focus on their expanding clinic. Libby evaluates her relationship with Bill and Virginia given their fractured triangle.